Freezing a tissue causes destruction by creating a burning effect on that tissue. Based on this logic, spraying liquid nitrogen on the wart freezes it and decays the wart tissue. In terms of recurrence rate, its effect is not different from that of other local treatment procedures. Since its destruction effect is limited, more than one session may be needed for the elimination of the same warts. Side effects of cryotherapy (freezing the warts off) include rashes, ulceration, and infection and discoloration due to local tissue destruction. Permanent scarring may rarely occur. It can be performed safely during pregnancy.